General Hospital Psychiatry
Volume 25, Issue 1 , Pages 59-60 , January 2003

Venous thromboembolism and clozapine: an association unresolved

References 

  1. Lieberman JA. Maximizing clozapine therapy (managing side effects). J Clin Psychiatry. 1998;59(Suppl 3):38–43
  2. Gupta S. Paradoxical hypertension associated with clozapine. Am J Psychiatry. 1994;151:148
  3. George TP, Winther LC. Hypertension after initiation of clozapine. Am J Psychiatry. 1996;153:1368–1369
  4. Pitner JK, Mintzer JE, Pennypacker LC, Jackson CW. Efficacy and adverse effects of clozapine in four elderly psychotic patients. J Clin Psychiatry. 1995;56:180–185
  5. Hameedi FA, Sernyak MJ, Navui SA, Kostan TR. Near syncope associated with concominant clozapine and cocaine use. J Clin Psychiatry. 1996;57:371–372
  6. Kilian JG, Kerr K, Lawrence C, Celermajer DS. Myocarditis and cardiomyopathy associated with clozapine. Lancet. 1999;354:1841–1845
  7. Devarajan S, Kutcher SP, Dursun SM. Clozapine and sudden death. Lancet. 2000;355:841
  8. Walker AM, Lanza LL, Arellano F, Rothman KJ. Mortality in current and former users of clozapine. Epidemiology. 1997;8:671–677
  9. Lacika S, Cooper JP. Pulmonary embolus possibly associated with clozapine treatment. Can J Psychiatry. 1999;44:396–397
  10. Coodin S, Ballegeer T. Clozapine therapy and pulmonary embolism. Can J Psychiatry. 2000;45:395
  11. Hagg S, Spigset O, Soderstroem TG. Association of venous thromboembolism and clozapine. Lancet. 2000;355:1155–1156
  12. Suttmann I, Dittert S, Landgraf R, Schulze J, Folwaczny C. Clozapine and sudden death. Lancet. 2000;355:842–843
  13. Ihde-Scholl T, Rolli ML, Jefferson JW. Clozapine and pulmonary embolus. Am J Psychiatry. 2001;158:499–500
  14. Zornberg GW, Jick H. Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism (a case-control study). Lancet. 2000;356:1219–1223
  15. Rodgers GM. Thrombosis and antithrombotic therapy. In: Lee GR, Lukens J, Greer JP, et al. (editors). Wintrobe’s clinical hematology. Vol. 2., 10th edition. Maryland: Williams & Wilkins, 1999. p. 1781–90
  16. Wolstein J, Grohmann R, Ruther E, Hippius H. Antipsychotic drugs and venous thromboembolism. Lancet. 2000;356:252

PII: S0163-8343(02)00254-2

doi: 10.1016/S0163-8343(02)00254-2

General Hospital Psychiatry
Volume 25, Issue 1 , Pages 59-60 , January 2003

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