General Hospital Psychiatry
Volume 25, Issue 2 , Pages 142-144 , March 2003

Provoked bradycardia after paroxetine administration

  • Chi-U.n Pae, MD*

      Affiliations

    • The Catholic University of Korea, College of Medicine, Kangnam St. Mary’s Hospital, Seoul, South Korea
    • ,
  • Jung-Jin Kim, MD, PhD

      Affiliations

    • The Catholic University of Korea, College of Medicine, Kangnam St. Mary’s Hospital, Seoul, South Korea
    • ,
  • Chang-U.k Lee, MD, PhD

      Affiliations

    • The Catholic University of Korea, College of Medicine, Kangnam St. Mary’s Hospital, Seoul, South Korea
    • ,
  • Soo-Jung Lee, MD, PhD

      Affiliations

    • The Catholic University of Korea, College of Medicine, Kangnam St. Mary’s Hospital, Seoul, South Korea
    • ,
  • Chul-Lee, MD, PhD

      Affiliations

    • The Catholic University of Korea, College of Medicine, Kangnam St. Mary’s Hospital, Seoul, South Korea
    • ,
  • I.n-H.o Paik, MD, PhD

      Affiliations

    • The Catholic University of Korea, College of Medicine, Kangnam St. Mary’s Hospital, Seoul, South Korea

References 

  1. Konig F, Hafele M, Hauger B, et al.  Bradycardia after beginning therapy with metoprolol and paroxetine. Psychiatr Prax. 1996;23:244–245
  2. Roose SP, Laghrissi-Thode F, Kennedy JS, et al.  Comparison of paroxetine, and nortriptyline in depressed patients with ischemic heart disease. JAMA. 1998;279:287–291
  3. Yeragani VK, Pohl R, Jampala VC, et al.  Effects of nortriptyline and paroxetine on QT variability in patients with panic disorder. Depress Anxiety. 2000;11:126–130
  4. Hemeryck A, Lefebvre RA, De Vriendt C, Belpaire FM. Paroxetine affects metoprolol pharmacokinetics, and pharmacodynamics in healthy volunteers. Clin Pharmacol Ther. 2000;67:283–291
  5. Graff DW, Williamson KM, Pieper JA, et al.  Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients. J Clin Pharmacol. 2001;41:97–106
  6. Morgan T. Clinical pharmacokinetics and pharmacodynamics of carvedilol. Clin Pharmacokinet. 1994;26:335–346
  7. Erfurth A, Loew M, Dobmeier P, Wendler G. ECG changes after paroxetine. 3 case reports. Nervenarzt. 1998;69:629–631
  8. Packer M, Bristow MR, Cohn JN, et al.  The effect of carvedilol on morbidity, and mortality in patients with chronic heart failure. U S Carvedilol Heart Failure Study Group N Engl J Med. 1996;334:1349–1355
  9. PDR. Physicians’ Desk Reference, 2002 (Hospital/Library Version). 56th edition. NJ: Medical Economics, 2002

PII: S0163-8343(02)00274-8

doi: 10.1016/S0163-8343(02)00274-8

General Hospital Psychiatry
Volume 25, Issue 2 , Pages 142-144 , March 2003

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