General Hospital Psychiatry
Volume 26, Issue 3 , Pages 199-209 , May 2004

The impact of a pharmacist intervention on 6-month outcomes in depressed primary care patients

  • David A Adler, M.D.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
    • Tufts University School of Medicine, Boston, MA, USA
    • Department of Psychiatry, Tufts-New England Medical Center (T-NEMC), Boston, MA, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-617-636-8755; fax: +1-617-636-8351.
  • ,
  • Kathleen M Bungay, Pharm.D.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
    • Tufts University School of Medicine, Boston, MA, USA
  • ,
  • Ira B Wilson, M.D., M.Sc.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
    • Tufts University School of Medicine, Boston, MA, USA
  • ,
  • Yu Pei, M.P.A.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
  • ,
  • Stacey Supran, M.Sc.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
  • ,
  • Emily Peckham, B.S.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
  • ,
  • Diane J Cynn, B.A.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA
  • ,
  • William H Rogers, Ph.D.

      Affiliations

    • Department of Medicine, The Health Institute, Division of Clinical Care Research, (T-NEMC), Boston, MA, USA

Received 31 January 2003 ,Accepted 12 August 2003.

References 

  1. Hunkeler EM, Meresman JF, Hargreaves WA, et al.  Efficacy of nurse telehealth care and peer support in augmenting treatment of depression in primary care. Arch Fam Med. 2000;9(8):700–708
  2. Zimmerman M, Coryell W. The validity of a self-report questionnaire for diagnosing major depressive disorder. Arch Gen Psychiatry. 1988;45(8):738–740
  3. Katon W, Von Korff M, Lin E, et al.  Collaborative management to achieve treatment guidelines. Impact on depression in primary care. JAMA. 1995;273(13):1026–1031
  4. Katon W, Robinson P, Von Korff M, et al.  A multifaceted intervention to improve treatment of depression in primary care. Arch Gen Psychiatry. 1996;53(10):924–932
  5. Katon W, Von Korff M, Lin E, et al.  Stepped collaborative care for primary care patients with persistent symptoms of depression (a randomized trial). Arch Gen Psychiatry. 1999;56(12):1109–1115
  6. Katon W, Rutter C, Ludman EJ, et al.  A randomized trial of relapse prevention of depression in primary care. Arch Gen Psychiatry. 2001;58(3):241–247
  7. Katzelnick DJ, Simon GE, Pearson SD, et al.  Randomized trial of a depression management program in high utilizers of medical care. Arch Fam Med. 2000;9(4):345–351
  8. Rost K, Nutting P, Smith J, Werner J, Duan N. Improving depression outcomes in community primary care practice (a randomized trial of the quest intervention). J Gen Intern Med. 2001;16(3):143–149
  9. Schade CP, Jones ER, Wittlin BJ. A ten-year review of the validity and clinical utility of depression screening. Psych Services. 1998;49(1):55–59
  10. Schulberg HC, Block MR, Madonia MJ, et al.  Treating major depression in primary care practice. Eight-Month clinical outcomes. Arch Gen Psychiatry. 1996;53:913–919
  11. Simon GE, Von Korff M, Rutter C, Wagner E. Randomised trial of monitoring, feedback, and management of care by telephone to improve treatment of depression in primary care. Br Med J. 2000;320(7234):550–554
  12. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD (the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire). JAMA. 1999;282(18):1737–1744
  13. Wells KB, Sherbourne C, Schoenbaum M, Duan N, et al.  Impact of disseminating quality improvement programs for depression in managed primary care (a randomized controlled trial). JAMA. 2000;283(2):212–220
  14. Sherbourne CD, Wells KB, Duan N, et al.  Long-term effectiveness of disseminating quality improvement for depression in primary care. Arch Gen Psychiatry. 2001;58(7):696–703
  15. Unutzer J, Rubenstein L, Katon WJ, et al.  Two-year effects of quality improvement programs on medication management for depression. Arch Gen Psychiatry. 2001;58(10):935–942
  16. Adler DA, Bungay KM. Treating depression in primary care: ‘best of times and worst of times’. Med Behav 1999;25-30
  17. Blazer DG, Kessler RC, McGonagle KA, Swartz MS. The prevalence and distribution of major depression in a national community sample (the National Comorbidity Survey). Am J Psychiatry. 1994;151(7):979–986
  18. Brown JB, Shye D, McFarland BH. The paradox of guideline implementation (how AHCPR's depression guideline was adapted at Kaiser Permanente northwest region). J Quality Improvement. 1995;21(1):5–21
  19. Depression Guidelines Panel. Depression in primary care: Volume 1. Detection and diagnosis. Volume 2. Treatment of major depression. Clinical Practice Guidelines Number 5. Rockville, MD: U S Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, 1993
  20. Greenberg PE, Stiglin LE, Finkelstein SN, Berndt ER. The economic burden of depression in 1990. J Clin Psychiatry. 1993;54(11):405–418
  21. Kessler LG, Cleary PD, Burke JDJ. Psychiatric disorders in primary care. Results of a follow-up study. Arch Gen Psychiatry. 1985;42(6):583–587
  22. Kessler RC, McGonagle KA, Zhao S, et al.  Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994;51(1):8–19
  23. Regier DA, Narrow WE, Rae DS, et al.  The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services. Arch Gen Psychiatry. 1993;50(2):85–94
  24. Rice DP, Miller LS. The economic burden of affective disorders. Br J Psychiatry Suppl 1995;(27):34-42
  25. Simon GE, Von Korff M, Barlow W. Health care costs of primary care patients with recognized depression. Arch Gen Psychiatry. 1995;52:850–856
  26. Sturm R, Wells KB. How can care for depression become more cost-effective?. JAMA. 1995;273(1):51–58
  27. U. S. Department of Health and Human Services. Mental health: a report of the Surgeon General. Rockville, MD: U. S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, NIH, NIMH, 1999
  28. U. S. Department of Health and Human Services. Healthy People 2010. Department of Health and Human Services 2000
  29. Wells KB, Hays RD, Burnam MA, et al.  Detection of depressive disorder for patients receiving prepaid or fee- for-service care. Results from the Medical Outcomes Study. JAMA. 1989;262(23):3298–3302
  30. Wells KB, Stewart A, Hays RD, et al.  The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. JAMA. 1989;262(7):914–919
  31. Wells KB, Sturm R. Care for depression in a changing environment. Health Aff (Millwood). 1995;14(3):78–89
  32. Whooley MA, Simon GE. Primary care (managing depression in medical outpatients). N Engl J Med. 2000;343(26):1942–1950
  33. Miranda J, Hohmann AA, Attkisson CC, Larson DB. Mental disorders in primary care. San Francisco: Jossey-Bass; 1994;
  34. Simon GE. Can depression be managed appropriately in primary care?. J Clin Psychiatry. 1998;59(Suppl 2):3–8
  35. Young AS, Klap R, Sherbourne C, Wells K. The quality of care for depression and anxiety disorders in the U. S. Arch Intern Med. 2001;58:55–61
  36. Nutting PA, Rost K, Smith J, Werner JJ, Elliot C. Competing demands from physical problems (effect on initiating and completing depression care over 6 months). Arch Fam Med. 2000;9(10):1059–1064
  37. Rost K, Nutting P, Smith J, et al.  The role of competing demands in the treatment provided primary care patients with major depression. Arch Fam Med. 2000;9(2):150–154
  38. Koike AK, Unutzer J, Wells KB. Improving the care for depression in patients with comorbid medical illness. Am J Psychiatry. 2002;159(10):1738–1745
  39. Moore RG. Improving the treatment of depression in primary care (problems and prospects). Br J Gen Pract. 1997;47(422):587–590
  40. Schulberg HC, Block MR, Madonia MJ, et al.  The ‘usual care’ of major depression in primary care practice. Arch Fam Med. 1997;6(4):334–339
  41. Katz SJ, Kessler RC, Lin E, Wells KB. Medication management of depression in the United States and Ontario. J Gen Intern Med. 1998;13(2):77–85
  42. Reimherr FW, Amsterdam JD, Quitkin FM, et al.  Optimal length of continuation therapy in depression (a prospective assessment during long-term fluoxetine treatment). Am J Psychiatry. 1998;155(9):1247–1253
  43. Wilkinson G, Allen P, Marshall E, et al.  The role of the practice nurse in the management of depression in general practice (treatment adherence to antidepressant medication). Psychol Med. 1993;23(1):229–237
  44. Pincus T, Sokka T, Stein CM. Pharmacist scope of practice. Ann Intern Med. 2002;136(1):79–85
  45. Curley C, McEachern JE, Speroff T. A firm trial of interdisciplinary rounds on the inpatient medical wards (an intervention designed using continuous quality improvement). Med Care. 1998;36(8 Suppl):AS4–12
  46. Strom BL, Hennessy S. Pharmacist care and clinical outcomes for patients with reactive airways disease. JAMA. 2002;288(13):1642–1643
  47. Sommers SD, Chaiyakunapruk N, Gardner JS, Winkler J. The emergency contraception collaborative prescribing experience in Washington State. J Am Pharm Assoc (Wash). 2001;41(1):60–66
  48. Kradjan WA, Schulz R, Christensen DB, et al.  Patients' perceived benefit from and satisfaction with asthma-related pharmacy services. J Am Pharm Assoc (Wash). 1999;39(5):658–666
  49. Lodwick AD, Sajbel TA. Patient and physician satisfaction with a pharmacist-managed anticoagulation clinic (implications for managed care organizations). Manag Care. 2000;9(2):47–50
  50. Weinberger M, Murray MD, Marrero DG, et al.  Effectiveness of pharmacist care for patients with reactive airways disease (a randomized controlled trial). JAMA. 2002;288(13):1594–1602
  51. Rogers WH, Wilson IB, Bungay KM, Cynn DJ, Adler DA. Assessing the performance of a new depression screener for primary care (PC-SAD(c)). J Clin Epidemiol. 2002;55(2):164–175
  52. Wells KB. The design of Partners in Care (evaluating the cost-effectiveness of improving care for depression in primary care). Soc Psychiatry Psychiatr Epidemiol. 1999;34(1):20–29
  53. Costa PT, McCrae RR. Normal personality assessment in clinical practice (the NEO personality inventory). Psychological Assessment. 1992;4(1):5–13
  54. Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 health survey: manual and interpretation guide. Boston MA: The Health Institute, New England Medical Center, 1993
  55. Ware JE, Kosinski M, Keller SD. SF-12: How to Score the SF-12 Physical & Mental Health Summary Scales, 2nd ed. Boston MA: The Health Institute New England Medical Center, 1995
  56. Tietze KJ. Taking medication histories. In:  Roche J editors. Clinical skills for pharmacists (A patient-focused approach). St. Louis, MO: Mosby-Year Book, Inc; 1997;p. 39–55
  57. Bungay KM, Adler DA, Rogers WH, et al. Description of a clinical pharmacist intervention administered to primary care patients with depression. Gen Hosp Psychiatry 2004;26:210–8
  58. Schoenbaum M, Unutzer J, Sherbourne C, et al.  Cost-effectiveness of practice-initiated quality improvement for depression (results of a randomized controlled trial). JAMA. 2001;286(11):1325–1330
  59. Kwon A, Bungay KM, Pei Y, et al.  Antidepressant use (concordance between self-report and claims records). Med Care. 2003;41(3):368–374
  60. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:53–63
  61. Beck AT, Steer RA. Manual for the beck depression inventory. San Antonio TX: Psychological Association; 1987;
  62. Zimmerman M, Mattia JI. A self-report scale to help make psychiatric diagnoses (the psychiatric diagnostic screening questionnaire). Arch Gen Psychiatry. 2001;58:787–794
  63. Rogers WH, Adler DA, Bungay KM, Wilson IB. Depression screening instruments make good severity measures. Submitted for publication, 2003
  64. Berwick DM, Murphy JM, Goldman PA, et al.  Performance of a five-item mental health screening test. Med Care. 1991;29(2):169–176
  65. Freedman D, Pisani R, Purves R. Statistics. New York: W.W. Norton and Co; 1978;
  66. Kraemer HC, Wilson GT, Fairburn CG, Agras WS. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry. 2002;59(10):877–883
  67. U. S. Department of Health and Human Services. Healthy People 2000. 91-50212. Washington, DC: Department of Health and Human Services, 1991
  68. Katon W, Von Korff M, Lin E, Bush T, Ormel J. Adequacy and duration of antidepressant treatment in primary care. Med Care. 1992;30(1):67–76

 Funding Source: Grant MH56214 from the National Institute of Mental Health, Rockville, MD

PII: S0163-8343(03)00116-6

doi: 10.1016/j.genhosppsych.2003.08.005

General Hospital Psychiatry
Volume 26, Issue 3 , Pages 199-209 , May 2004