General Hospital Psychiatry
Volume 29, Issue 3 , Pages 275-277 , May 2007

Nocebo effects with antidepressant clinical drug trial placebos

  • Roy R. Reeves, D.O., Ph.D.

      Affiliations

    • G.V. (Sonny) VA Medical Center, Mental Health Service (11M), 1500 E. Woodrow Wilson Drive, Jackson, MS 39216, USA
    • University of Mississippi School of Medicine, Department of Psychiatry, 2500 N. State Street, Jackson, MS 39216, USA
    • Corresponding Author InformationCorresponding author. VA Medical Center, Jackson, MS 39216, USA. Tel.: +1 601 368 4159; fax: +1 601 364 1395.
    • ,
  • Mark E. Ladner, M.D.

      Affiliations

    • G.V. (Sonny) VA Medical Center, Mental Health Service (11M), 1500 E. Woodrow Wilson Drive, Jackson, MS 39216, USA
    • University of Mississippi School of Medicine, Department of Psychiatry, 2500 N. State Street, Jackson, MS 39216, USA
    • ,
  • Roy H. Hart, M.D.

      Affiliations

    • G.V. (Sonny) VA Medical Center, Mental Health Service (11M), 1500 E. Woodrow Wilson Drive, Jackson, MS 39216, USA
    • ,
  • Randy S. Burke, Ph.D.

      Affiliations

    • G.V. (Sonny) VA Medical Center, Mental Health Service (11M), 1500 E. Woodrow Wilson Drive, Jackson, MS 39216, USA
    • University of Mississippi School of Medicine, Department of Psychiatry, 2500 N. State Street, Jackson, MS 39216, USA

Received 9 November 2006 ,Accepted 17 January 2007.

References 

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  2. Hahn RA. The nocebo phenomenon: concept, evidence, and implications for public health. Prev Med. 1997;26:607–611
  3. Flaten MA, Simonsen T, Olsen H. Drug-related information generates placebo and nocebo responses that modify the drug response. Psychosom Med. 1999;61:250–255
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  11. Mayberg HS, Silva JA, Brannan SK, et al. The functional neuroanatomy of the placebo effect. Am J Psychiatry. 2002;159:728–737
  12. Leuchter AF, Cook IA, Witte EA, et al. Changes in brain function of depressed patients during treatment with placebo. Am J Psychiatry. 2002;159:122–129
  13. Hunter AM, Leuchter AF, Morgan ML, Cook IA. Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression. Am J Psychiatry. 2006;163:1426–1432
  14. Barsky AJ, Saintford R, Rogers MP, Borus JF. Nonspecific medication side effects and the nocebo phenomenon. JAMA. 2002;287:622–627
  15. Brown WA. Placebo as a treatment for depression. Neuropsychopharmacology. 1994;10:265–269
  16. Khan A, Warner HA, Brown WA. Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials. Arch Gen Psychiatry. 2000;57:311–317
  17. Kirsch I, Sapirstein G. Listening to Prozac but hearing placebo: a meta-analysis of antidepressant medication. Prevention and treatment. 1998;Article 0002a. http://journals@apa.org/prevention/volume1/pre0010002a.html
  18. Loebel AD, Hyde TS, Dunner DL. Early placebo response in anxious and depressed patients. J Clin Psychiatry. 1986;47:230–233

PII: S0163-8343(07)00011-4

doi: 10.1016/j.genhosppsych.2007.01.010

General Hospital Psychiatry
Volume 29, Issue 3 , Pages 275-277 , May 2007

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