General Hospital Psychiatry
Volume 30, Issue 5 , Pages 421-434 , September 2008

Posttraumatic stress disorder in general intensive care unit survivors: a systematic review

  • Dimitry S. Davydow, M.D.

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, University of Washington School of Medicine, Box 356896, Seattle, WA 98104, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 206 744 4467; fax: +1 206 744 3427.
    • ,
  • Jeneen M. Gifford, M.D.

      Affiliations

    • Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    • ,
  • Sanjay V. Desai, M.D.

      Affiliations

    • Section of Pulmonary, Critical Care and Respiratory Services, Washington Hospital Center, Washington, DC 20817, USA
    • ,
  • Dale M. Needham, M.D., Ph.D.

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    • ,
  • O. Joseph Bienvenu, M.D., Ph.D.

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA

Received 22 March 2008 ,Accepted 28 May 2008.

References 

  1. National Quality Measures Clearinghouse . Intensive care: percentage of adult patients having had an intensive care unit (ICU) stay whose hospital outcome is death. http://www.qualitymeasures.ahrq.gov/summary/summary.aspx?doc_id=8026Accessed March 21, 2008
  2. Angus DC, Carlet J. Surviving intensive care: a report from the 2002 Brussels Roundtable. Intensive Care Med. 2003;29:368–377
  3. Broomhead LR, Brett SJ. Clinical review: intensive care follow-up — what has it told us?. Crit Care. 2002;6:411–417
  4. Dowdy DW, Eid MP, Sedrakyan A, et al. Quality of life in adult survivors of critical illness: a systematic review of the literature. Intensive Care Med. 2005;31:611–620
  5. Hopkins RO, Jackson JC. Long-term neurocognitive function after critical illness. Chest. 2006;130:869–878
  6. Jones C, Griffiths RD, Humphris G. Disturbed memory and amnesia related to intensive care. Memory. 2000;8:79–94
  7. Jackson JC, Hart RP, Gordon SM, et al. Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem. Crit Care. 2007;11:R27
  8. Griffiths J, Fortune G, Barber V, Young JD. The prevalence of post traumatic stress disorder in survivors of ICU treatment: a systematic review. Intensive Care Med. 2007;33:1506–1518
  9. Davydow DS, Desai SV, Needham DM, Bienvenu OJ. Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med. 2008;70:512–519
  10. Perrins J, King N, Collings J. Assessment of long-term psychological well-being following intensive care. Intensive Crit Care Nurs. 1998;14:108–116
  11. Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med. 2001;29:573–580
  12. Samuelson KAM, Lundberg D, Fridlund B. Stressful memories and psychological distress in adult mechanically ventilated intensive care patients: a 2-month follow-up study. Acta Anaesthesiol Scand. 2007;51:671–678
  13. Jones C, Backman C, Capuzzo M, et al. Precipitants of post-traumatic stress disorder following intensive care: a hypothesis generating study of diversity in care. Intensive Care Med. 2007;33:978–985
  14. Cuthbertson BH, Hull A, Strachan M, Scott J. Post-traumatic stress disorder after critical illness requiring general intensive care. Intensive Care Med. 2004;30:450–455
  15. Jones C, Skirrow P, Griffiths RD, et al. Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med. 2003;31:2456–2461
  16. Sukantarat K, Greer S, Brett S, Williamson R. Physical and psychological sequelae of critical illness. Br J Health Psychol. 2007;12:65–74
  17. Griffiths J, Gager M, Alder N, et al. A self-report-based study of the incidence and associations of sexual dysfunction in survivors of intensive care treatment. Intensive Care Med. 2006;32:445–451
  18. Girard TD, Shintani AK, Jackson JC, et al. Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care. 2007;11:R28
  19. Nickel M, Leiberich P, Nickel C, et al. The occurrence of posttraumatic stress disorder in patients following intensive care treatment: a cross-sectional study in a random sample. J Intensive Care Med. 2004;19:285–290
  20. Rattray JE, Johnston M, Wildsmith JA. Predictors of emotional outcomes of intensive care. Anaesthesia. 2005;60:1085–1092
  21. Kress JP, Gehlbach B, Lacy M, et al. The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med. 2003;168:1457–1461
  22. Scragg P, Jones A, Fauvel N. Psychological problems following ICU treatment. Anaesthesia. 2001;56:9–14
  23. Schelling G, Briegel J, Roozendaal B, et al. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biol Psychiatry. 2001;50:978–985
  24. Schelling G, Stoll C, Kapfhammer HP, et al. The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors. Crit Care Med. 1999;27:2678–2683
  25. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care. 1992;30:473–483
  26. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:617–627
  27. Spindler H, Pedersen SS. Posttraumatic stress disorder in the wake of heart disease: prevalence, risk factors, and future research directions. Psychosom Med. 2005;67:715–723
  28. Brewin CR, Andrews B, Valentine JD. Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clinical Psychol. 2000;68:748–766
  29. Malik ML, Connor KM, Sutherland SM, et al. Quality of life and posttraumatic stress disorder: a pilot study assessing changes in SF-36 scores before and after treatment in a placebo-controlled trial of fluoxetine. J Trauma Stress. 1999;12:387–393
  30. Zatzick DF, Marmar CR, Weiss DS, et al. Posttraumatic stress disorder and functioning and quality of life outcomes in a nationally representative sample of male Vietnam veterans. Am J Psychiatry. 1997;154:1690–1695
  31. Stoll C, Kapfhammer HP, Rothenhausler HB, et al. Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med. 1999;25:697–704
  32. Bienvenu OJ, Stein MB. Personality and anxiety disorders: a review. J Personal Disord. 2003;17:139–151
  33. Bramsen I, Dirkzwager AJ, van der Ploeg HM. Predeployment personality traits and exposure to trauma as predictors of posttraumatic stress symptoms: a prospective study of former peacekeepers. Am J Psychiatry. 2000;157:1115–1119
  34. Breslau N. Epidemiologic studies of trauma, posttraumatic stress disorder, and other psychiatric disorders. Can J Psychiatry. 2002;47:923–929
  35. Fauerbach JA, Lawrence JW, Schmidt CW, Munster AM, Costa PT. Personality predictors of injury-related posttraumatic stress disorder. J Nerv Ment Dis. 2000;188:510–517
  36. McAvay GJ, Van Ness PH, Bogardus ST, et al. Depressive symptoms and the risk of incident delirium in older hospitalized adults. J Am Geriatr Soc. 2007;55:684–691
  37. Minden SL, Carbone LA, Barsky A, et al. Predictors and outcomes of delirium. Gen Hosp Psychiatry. 2005;27:209–214
  38. Pompei P, Foreman M, Rudberg M, et al. Delirium in hospitalized older persons: outcomes and predictors. J Am Geriatr Soc. 1994;42:809–815
  39. Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298:2644–2653
  40. Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30:119–141
  41. Capuron L, Miller AH. Cytokines and psychopathology: lessons from interferon-alpha. Biol Psychiatry. 2005;56:819–824
  42. Musselman DL, Miller AH, Porter MR, et al. Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. Am J Psychiatry. 2001;158:1252–1257
  43. Schelling G, Kilger E, Roozendaal B, et al. Stress doses of hydrocortisone, traumatic memories, and symptoms of posttraumatic stress disorder in patients after cardiac surgery: a randomized study. Biol Psychiatry. 2004;55:627–633
  44. Weis F, Kilger E, Roozendaal B, et al. Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: a randomized study. J Thorac Cardiovasc Surg. 2006;131:277–282
  45. Boer KR, van Ruler O, van Emmeril AAP, et al. Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram. Intensive Care Med. 2008;34:664–674
  46. Shalev AY, Segman RH. Commentary: biological findings in PTSD — too much or too little?. Prog Brain Res. 2008;167:187–199

☆ Dr. Needham is supported by a Clinician-Scientist Award from the Canadian Institutes of Health Research and by the National Institutes of Health (Acute Lung Injury SCCOR Grant # P050 HL73994). Dr. Bienvenu is supported by a Career Development Award from the National Institutes of Health (K23 MH64543).

PII: S0163-8343(08)00080-7

doi: 10.1016/j.genhosppsych.2008.05.006

General Hospital Psychiatry
Volume 30, Issue 5 , Pages 421-434 , September 2008

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