General Hospital Psychiatry
Volume 31, Issue 6 , Pages 586-588 , November 2009

Schizophrenia-like psychotic episode precipitated by cobalamin deficiency

Received 10 November 2008 ,Accepted 17 February 2009.

References 

  1. Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988;318:1720–1728
  2. Catalano G, Catalano MC, O'Dell KJ, Humphrey DA, Fritz EB. The utility of laboratory screening in medically III patients with psychiatric symptoms. Ann Clin Psychiatry. 2001;13:135–140
  3. Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996;54:382–390
  4. Holmes JM. Cerebral manifestations of vitamin-B12 deficiency. Br Med J. 1956;2:1394–1398
  5. Unrecognized cobalamin-responsive neuropsychiatric disorders. Nutr Rev. 1989;47:208–210
  6. Rao NP, Kumar NC, Raman BR, Sivakumar PT, Pandey RS. Role of vitamin B12 in depressive disorder — a case report. Gen Hosp Psychiatry. 2008;30:185–186
  7. Ii Y, Kuzuhara S. Dementia associated with vitamin B12 deficiency. Nippon Rinsho. 2004;(62 Suppl):365–367
  8. Goebels N, Soyka M. Dementia associated with vitamin B(12) deficiency: presentation of two cases and review of the literature. J Neuropsychiatry Clin Neurosci. 2000;12:389–394
  9. Berry N, Sagar R, Tripathi BM. Catatonia and other psychiatric symptoms with vitamin B12 deficiency. Acta Psychiatr Scand. 2003;108:156–159
  10. Buchman N, Mendelsson E, Lerner V, Kotler M. Delirium associated with vitamin B12 deficiency after pneumonia. Clin Neuropharmacol. 1999;22:356–358
  11. Masalha R, Chudakov B, Muhamad M, et al. Cobalamin-responsive psychosis as the sole manifestation of vitamin B12 deficiency. Isr Med Assoc J. 2001;3:701–703
  12. Rajkumar AP, Jebaraj P. Chronic psychosis associated with vitamin B12 deficiency. J Assoc Physicians India. 2008;56:115–116
  13. Herr KD, Norris ER, Frankel BL. Acute psychosis in a patient with vitamin B(12) deficiency and coincident cervical stenosis. Psychosomatics. 2002;43:234–236
  14. Shanoudy H, Salem AG. Neuropsychiatric manifestations of vitamin B12 deficiency in the absence of anemia or macrocytosis: a case report. S D J Med. 1992;45:129–131
  15. Marks PW, Zukerberg LR. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 30-2004. A 37-year-old woman with paresthesias of the arms and legs. N Engl J Med. 2004;351:1333–1341
  16. Mitsuyama Y, Kogoh H. Serum and cerebrospinal fluid vitamin B12 levels in demented patients with CH3-B12 treatment — preliminary study. Jpn J Psychiatry Neurol. 1988;42:65–71
  17. Aaron S, Kumar S, Vijayan J, et al. Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes. Neurol India. 2005;53:55–58[discussion 59]
  18. Hutto BR. Folate and cobalamin in psychiatric illness. Compr Psychiatry. 1997;38:305–314
  19. Herbert V. Staging vitamin B-12 (cobalamin) status in vegetarians. Am J Clin Nutr. 1994;59:1213S–1222S
  20. Herrmann W, Geisel J. Vegetarian lifestyle and monitoring of vitamin B-12 status. Clin Chim Acta. 2002;326:47–59
  21. Martin DC, Francis J, Protetch J, Huff FJ. Time dependency of cognitive recovery with cobalamin replacement: report of a pilot study. J Am Geriatr Soc. 1992;40:168–172
  22. O'Neill D, Barber RD. Reversible dementia caused by vitamin B12 deficiency. J Am Geriatr Soc. 1993;41:192–193
  23. Dommisse J. Subtle vitamin-B12 deficiency and psychiatry: a largely unnoticed but devastating relationship?. Med Hypotheses. 1991;34:131–140
  24. Evans DL, Edelsohn GA, Golden RN. Organic psychosis without anemia or spinal cord symptoms in patients with vitamin B12 deficiency. Am J Psychiatry. 1983;140:218–221

PII: S0163-8343(09)00017-6

doi: 10.1016/j.genhosppsych.2009.02.003

General Hospital Psychiatry
Volume 31, Issue 6 , Pages 586-588 , November 2009