General Hospital Psychiatry
Volume 32, Issue 2 , Pages 156-163 , March 2010

Hospital admissions due to physical disease in people with schizophrenia: a national population-based study

  • Carmen Bouza, M.D., Ph.D.

      Affiliations

    • Health-Care Technology Assessment Agency, Instituto de Salud Carlos III, 28029 Madrid, Spain
    • Corresponding Author InformationCorresponding author. Fax: +34 913877841.
  • ,
  • Teresa López-Cuadrado, M.Sc. Statistics

      Affiliations

    • National Epidemiology Centre, Instituto de Salud Carlos III, 28029 Madrid, Spain
  • ,
  • José María Amate, Ph.D.

      Affiliations

    • Health-Care Technology Assessment Agency, Instituto de Salud Carlos III, 28029 Madrid, Spain

Received 22 July 2009 ,Accepted 19 November 2009.

References 

  1. World Health Organization . The global burden of disease. Cambridge (MA): Harvard University Press; 1997;
  2. Rice DP. The economic impact of schizophrenia. J Clin Psychiatry. 1999;60(S1):4–6
  3. Goldner ERN, Waraich P, Somers JM. Prevalence and incidence of schizophrenic disorders: a systematic review of the literature. Can J Psychiatry. 2002;47:833–843
  4. Allebeck P. Schizophrenia: a life-shortening disease. Schizophr Bull. 1989;15:81–89
  5. Brown S. Excess mortality of schizophrenia. A meta-analysis. Br J Psychiatry. 1997;171:502–508
  6. Harris EC, Barraclough B. Excess mortality of mental disorder. Br J Psychiatry. 1998;173:11–53
  7. Jeste DV, Gladsjo JA, Lindamer LA, Lacro JP. Medical comorbidity in schizophrenia. Schizophr Bull. 1996;22:413–430
  8. Dixon L, Postrado L, Delahanty J, Fischer PJ, Lehman A. The association of medical comorbidity in schizophrenia with poor physical and mental health. J Nerv Ment Dis. 1999;187:496–502
  9. Goldman LS. Medical illness in patients with schizophrenia. J Clin Psychiatry. 1999;60(S21):10–15
  10. Marder SR, Essock SM, Miller AL, et al. Physical health monitoring of patients with schizophrenia. Am J Psychiatry. 2004;161:1334–1349
  11. Goff DC, Cather C, Evins AE, et al. Medical morbidity and mortality in schizophrenia: guidelines for psychiatrists. J Clin Psychiatry. 2005;66:183–194
  12. Chwastiak LA, Rosenheck RA, McEvoy JP, et al. Interrelationships of psychiatric symptom severity, medical comorbidity, and functioning in schizophrenia. Psychiatr Serv. 2006;57:1102–1109
  13. Green AI, Canuso CM, Brenner MJ, Wojcik JD. Detection and management of comorbidity in patients with schizophrenia. Psychiatr Clin North Am. 2003;26:115–139
  14. Leucht S, Burkard T, Henderson J, Maj M, Sartorius N. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr Scand. 2007;116:317–333
  15. Salokangas RK. Medical problems in schizophrenia patients living in the community (alternative facilities). Curr Opin Psychiatry. 2007;20:402–405
  16. Munk-Jorgensen P, Mors O, Mortensen PB, Ewald H. The schizophrenic patient in the somatic hospital. Acta Psychiatr Scand. 2000;102(S407):96–99
  17. Dixon L, Weiden P, Delahanty J, et al. Prevalence and correlates of diabetes in national schizophrenia samples. Schizophr Bull. 2000;26:903–912
  18. Cournos F, McKinnon K, Sullivan G. Schizophrenia and comorbid human immunodeficiency virus or hepatitis C virus. J Clin Psychiatry. 2005;66(S6):27–33
  19. Folsom DP, McCahill M, Bartels SJ, et al. Medical comorbidity and receipt of medical care by older homeless people with schizophrenia or depression. Psychiatr Serv. 2002;53:1456–1460
  20. Carney CP, Jones L, Woolson RF. Medical comorbidity in women and men with schizophrenia: a population-based controlled study. J Gen Intern Med. 2006;21:1133–1137
  21. Makikyro T, Karvonen JT, Hakko H, et al. Comorbidity of hospital-treated psychiatric and physical disorders with special reference to schizophrenia: a 28 year follow-up of the 1966 northern Finland general population birth cohort. Public Health. 1998;112:221–228
  22. Daumit GL, Pronovost PJ, Anthony CB, et al. Adverse events during medical and surgical hospitalizations for persons with schizophrenia. Arch Gen Psychiatry. 2006;63:267–272
  23. Kilbourne AM, Cornelius JR, Han X, et al. General-medical conditions in older patients with serious mental illness. Am J Geriatr Psychiatry. 2005;13:250–254
  24. Garcia J, Vázquez-Barquero J. Deinstitutionalization and psychiatric reform in Spain. Actas Esp Psiquiatr. 1999;27:281–291
  25. Vázquez-Barquero JL, García J, Torres-González F. Spanish psychiatric reform: what can be learned from two decades of experience?. Acta Psychiatr Scand Suppl. 2001;410:89–95
  26. Ministerio de Sanidad y Consumo. Sistema de Información Sanitaria Servicio Nacional de Salud. [http://www.msc.es/en/estadEstudios/estadisticas/sisInfSanSNS/home.htm]
  27. Demography and Population. Instituto Nacional de Estadística [http://www.ine.es/inebmenu/mnu_cifraspob.htm]
  28. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613–619
  29. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383
  30. Librero J, Peiró S, Ordiñana R. Chronic comorbidity and outcomes of hospital care: length of stay, mortality and readmission at 30 and 365 days. J Clin Epidemiol. 1999;52:171–179
  31. Estève J, Benhamou E, Raymond L. Méthodes statistiques en épidémiologie descriptive. Paris: Les éditions INSERM; 1993;
  32. Gulbinat W, Dupont A, Jablensky A, et al. Cancer incidence of schizophrenic patients. Results of record linkage studies in three countries. Br J Psychiatry Suppl. 1992;18:75–83
  33. Leung A, Chue P. Sex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand Suppl. 2000;401:3–38
  34. Lindamer LA, Bailey A, Hawthorne W, et al. Gender differences in characteristics and service use of public mental health patients with schizophrenia. Psychiatr Serv. 2003;54:1407–1409
  35. Bressi SK, Marcus SC, Solomon PL. The impact of psychiatric comorbidity on general hospital length of stay. Psychiatr Q. 2006;77:203–209
  36. Jeste DV, Unützer J. Improving the delivery of care to the seriously mentally ill. Med Care. 2001;39:907–909
  37. Brown S, Birtwistle J, Roe L, Thompson C. The unhealthy lifestyle of people with schizophrenia. Psychol Med. 1999;29:697–701
  38. Lambert TJR, Velakoulis D, Pantelis C. Medical comorbidity in schizophrenia. Med J Aust. 2003;178:s67–s70
  39. Newcomer JW. Medical risk in patients with bipolar disorder and schizophrenia. J Clin Psychiatry. 2006;67(S9):25–30
  40. Mitchell AJ, Malone D. Physical health and schizophrenia. Curr Opin Psychiatry. 2006;19:432–437
  41. Fleischhacker WW, Cetkovich-Bakmas M, De Hert M, et al. Comorbid somatic illnesses in patients with severe mental disorders: clinical, policy, and research challenges. J Clin Psychiatry. 2008;69:514–519
  42. Kane JM. Creating a health care team to manage chronic medical illnesses in patients with severe mental illness: the public policy perspective. J Clin Psychiatry. 2009;70(suppl 3):37–42
  43. Kisely S, Smith M, Lawrence D, et al. Inequitable access for mentally ill patients to some medically necessary procedures. CMAJ. 2007;176:779–784
  44. Laursen TM, Munk-Olsen T, Agerbo E, Gasse C, Mortensen PB. Somatic hospital contacts, invasive cardiac procedures, and mortality from heart disease in patients with severe mental disorder. Arch Gen Psychiatry. 2009;66:713–720
  45. Nazareth I, King M, Haines A, Rangel L, Myers S. Accuracy of diagnosis of psychosis on general practice computer system. BMJ. 1993;307:32–34
  46. Lawrenson R, Williams T, Farmer R. Clinical information for research; the use of general practice databases. J Public Health Med. 1999;21:299–304
  47. Byrne N, Regan C, Howard L. Administrative registers in psychiatric research: a systematic review of validity studies. Acta Psychiatr Scand. 2005;112:409–414

PII: S0163-8343(09)00242-4

doi: 10.1016/j.genhosppsych.2009.11.014

General Hospital Psychiatry
Volume 32, Issue 2 , Pages 156-163 , March 2010