General Hospital Psychiatry
Volume 32, Issue 5 , Pages 559.e1-559.e3 , September 2010

A case of methamphetamine use disorder treated with the antibiotic drug minocycline

  • Yuko Tanibuchi, M.D.

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
    • Fukaya Mental Clinic, Fukaya, Saitama, Japan
    • Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. Tel.: +81 43 226 2149; fax: +81 43 226 2150.
    • ,
  • Minoru Shimagami, M.D.

      Affiliations

    • Fukaya Mental Clinic, Fukaya, Saitama, Japan
    • ,
  • Goro Fukami, M.D., Ph.D.

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
    • ,
  • Yoshimoto Sekine, M.D., Ph.D.

      Affiliations

    • Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Chiba, Japan
    • ,
  • Masaomi Iyo, M.D., Ph.D.

      Affiliations

    • Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
    • ,
  • Kenji Hashimoto, Ph.D.

      Affiliations

    • Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan

Received 2 June 2009 ,Accepted 16 December 2009.

References 

  1. Ujike H, Sato M. Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis. Ann NY Acad Sci. 2004;1025:279–287
  2. Hashimoto K. New research on methamphetamine abuse. In:  Toolaney GH editors. New Research on Methamphetamine Abuse. New York: NovaScience Publishers, Inc.; 2007;p. 1–51
  3. Sekine Y, Iyo M, Ouchi Y, Matsunaga T, Tsukada H, Okada H, et al. Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET. Am J Psychiatry. 2001;158:1206–1214
  4. Sekine Y, Ouchi Y, Takei N, Yoshikawa E, Nakamura K, Futatsubashi M, et al. Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Arch Gen Psychiatry. 2006;63:90–100
  5. Schuckit MA, Saunders JB. The empirical basis of substance use disorders diagnosis: research recommendations for the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). Addiction. 2006;101(Suppl 1):170–173
  6. Volkow ND, Fowler JS, Wang GJ, Baler R, Telang F. Imaging dopamine's role in drug abuse and addiction. Neuropharmacology. 2009;56(Suppl 1):3–8Epub 2008
  7. Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, et al. Methamphetamine causes microglial activation in the brain of human abusers. J Neurosci. 2008;28:5756–5761
  8. Hashimoto K. Microglial activation and minocycline treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1758–1759
  9. Zhang L, Kitaichi K, Fujimoto Y, Nakayama H, Shimizu E, Iyo M, et al. Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine. Prog Neuro-Psychopharmacol Biol Psychiatry. 2006;30:1381–1393
  10. Hashimoto K, Tsukada H, Nishiyama S, Fukumoto D, Kakiuchi T, Iyo M. Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: a PET study in conscious monkeys. Biol Psychiatry. 2007;61:577–581
  11. Miyaoka T, Yasukawa R, Yasuda H, Hayashida M, Inagaki T, Horiguchi J. Minocycline as adjunctive therapy for schizophrenia: an open-label study. Clin Neuropharmacol. 2008;31:287–292
  12. Levkovitz Y, Mendlovich S, Issaki S, Braw Y, Levkovitz-Verbin H, Gal G, et al. A double blind randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry. 2009;Nov. 3. [Epub ahead of print]
  13. Hashimoto K. Minocycline as a therapeutic drug for methamphetamine use disorders. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008;28:19–22

☆ No authors had any disclosures to make.

PII: S0163-8343(09)00285-0

doi: 10.1016/j.genhosppsych.2009.12.005

General Hospital Psychiatry
Volume 32, Issue 5 , Pages 559.e1-559.e3 , September 2010

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