General Hospital Psychiatry
Volume 33, Issue 1 , Pages 82.e5-82.e7 , January 2011

A man who wanted to commit suicide by hanging himself: an adverse effect of ciprofloxacin

  • Amir I.A. Ahmed, M.D.

      Affiliations

    • Department of Elderly, GGZ-Noord-en Midden Limburg, 5803 AC, Venray, The Netherlands
    • Department of Clinical Pharmacology and Toxicology, The Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    • Corresponding Author InformationCorresponding author. Department of Clinical Pharmacology and Toxicology, The Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Tel.: +31 24 3614639; fax: +31 24 3614214.
  • ,
  • Frank M.M.A. van der Heijden, M.D., Ph.D.

      Affiliations

    • Department of Adult Psychiatry, GGZ-Noord-en Midden Limburg, 5803 AC, Venray, The Netherlands
  • ,
  • Hanneke van den Berkmortel, M.D.

      Affiliations

    • Department of Adult Psychiatry, GGZ-Noord-en Midden Limburg, 5803 AC, Venray, The Netherlands
  • ,
  • Kees Kramers, M.D., Ph.D.

      Affiliations

    • Department of Clinical Pharmacology and Toxicology, The Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Received 4 June 2010 ,Accepted 6 July 2010.

References 

  1. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–245
  2. Owens RC, Ambrose PG. Clinical use of the fluoroquinolones. Med Clin North Am. 2000;84(6):1447–1469
  3. Owens RC, Ambrose PG. Antimicrobial safety: focus on fluoroquinolones. Clin Infect Dis. 2005;41(Suppl 2):S144–S157
  4. Schacht P, Arcieri G, Hullmann R. Safety of oral ciprofloxacin: an update based on clinical trial results. Am J Med. 1989;87(5A):98S–102S
  5. Steinert T, Studemund H. Acute delusional parasitosis under treatment with ciprofloxacin. Pharmacopsychiatry. 2006;39(4):159–160
  6. Agbaht K, Bitik B, Piskinpasa S, et al. Ciprofloxacin-associated seizures in a patient with underlying thyrotoxicosis: case report and literature review. Int J Clin Pharmacol Ther. 2009;47(5):303–310
  7. Christ W. Central nervous system toxicity of quinolones: human and animal findings. J Antimicrob Chemother. 1990;26(Suppl B):219–225
  8. LaSalvia EA, Domek GJ, Gitlin DF. Fluoroquinolone-induced suicidal ideation. Gen Hosp Psychiatry. 2010;32(1):108–110
  9. Olivier P, Bertrand L, Tubery M, et al. Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey. Drugs Aging. 2009;26(6):475–482
  10. Bednarczyk EM, Adler LP, Remler B, et al. Assessment of the effects of ciprofloxacin and nalidixic acid on cerebral blood flow and metabolism in healthy subjects by positron emission tomography. Pharmacotherapy. 1994;14:153–161
  11. Unseld E, Zeilger G, Gemeinhardt A, et al. Possible interaction of fluoroquinolones with the benzodiazepine–GABA A-receptor complex. Br J Clin Pharmacol. 1990;30:63–70
  12. Peeters BW, Vanderheyden PM. In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site. Epilepsy Res. 1992;12(2):157–162
  13. Stahlmann R. Clinical toxicological aspects of fluoroquinolones. Toxicol Lett. 2002;127(1-3):269–277
  14. Radandt JM, Marchbanks CR, Dudley MN. Interactions of fluoroquinolones with other drugs: mechanisms, variability, clinical significance, and management. Clin Infectious Diseases. 1992;14:272–284
  15. Robertson HT, Allison DB. Drugs associated with more suicidal ideations are also associated with more suicide attempts. PLoS One. 2009;4(10):e7312
  16. McLellan RA, Drobitch RK, Monshouwer M, et al. Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human. Drug Metab Dispos. 1996;24:1134–1138
  17. Herrlin K, Segerdahl M, Gustafsson LL, et al. Methadone, ciprofloxacin, and adverse drug reactions. Lancet. 2000;356:2069–2070
  18. Zanchetti A, Omboni S, La Commare P, et al. Efficacy, tolerability, and impact on quality of life of long-term treatment with manidipine or amlodipine in patients with essential hypertension. J Cardiovasc Pharmacol. 2001;38(4):642–650
  19. de la Rosette JJ, Ruijgrok MC, Jeuken JM, et al. Personality variables involved in chronic prostatitis. Urology. 1993;42:654–662
  20. Berghuis JP, Heiman JR, Rothman I, et al. Psychological and physical factors involved in chronic idiopathic prostatitis. J Psychosom Res. 1996;41:313–325
  21. Egan KJ, Krieger JN. Psychological problems in chronic prostatitis patients with pain. Clin J Pain. 1994;10:218–226
  22. Reddy DS, Jian K. The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABA-A receptors. J Pharmacol Exp Ther. 2010;

PII: S0163-8343(10)00140-4

doi: 10.1016/j.genhosppsych.2010.07.002

General Hospital Psychiatry
Volume 33, Issue 1 , Pages 82.e5-82.e7 , January 2011